Time and place: mapping human prenatal macrophages across tissues.
Wagner C, Guilliams M.
Cell Res, 2024. Pubmed

In vivo macrophage engineering as novel therapeutic strategy against liver metastasis.
Laviron M, Guilliams M.
Trends Cancer, 2024. Pubmed

SPArrOW: a flexible, interactive and scalable pipeline for spatial transcriptomics analysis.
Pollaris L^*, Vanneste B^*, Rombaut B, Defauw A, Vernaillen F, Mortier J, Vanhenden W, Martens L, Thoné T, Hastir JF, Bujko A, Saelens W, Marine JC, Nelissen H, Van Hamme E, Seurinck R, Scott CL, Guilliams M⁺ and Saeys Y⁺.
bioRxiv, 2024. Pubmed

Infection history imprints prolonged changes to the epigenome, transcriptome and function of Kupffer cells. Musrati MA^*, Stijlemans B^*, Azouz A, Kancheva D, Mesbahi S, Hadadi E, Lebegge E, Ali L, De Vlaminck K, Scheyltjens I, Vandamme N, Zivalj M, Assaf N, Elkrim Y, Ahmidi I, Huart C, Lamkanfi M, Guilliams M, De Baetselier P, Goriely S, Movahedi K⁺, Van Ginderachter JA⁺.
Journal of Hepatol, 2024. Pubmed

A complement atlas identifies interleukin-6-dependent alternative pathway dysregulation as a key druggable feature of COVID-19. Van Damme KFA, Hoste L, Declercq J, De Leeuw E, Maes B, Martens L, Colman R, Browaeys R, Bosteels C, Verwaerde S, Vermeulen N, Lameire S, Debeuf N, Deckers J, Stordeur P, Depuydt P, Van Braeckel E, Vandekerckhove L, Guilliams M, Schetters STT, Haerynck F, Tavernier SJ, Lambrecht BN.
Sci Transl Med, 2023. Pubmed

The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function.
Iliakis CS, Kulikauskaite J, Aegerter H, Li F, Piattini F, Jakubzick CV, Guilliams M, Kopf M, Wack A.
Nature Immunol, 2023. Pubmed

Macrophage superclusters to the rescue.
Louwe PA, Guilliams M.
Science, 2023. Pubmed

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches.
Guilliams M^*, Bonnardel J^*, Haest B^*, Vanderborght B^*, Wagner C, Remmerie A, Bujko A, Martens L, Thoné T, Browaeys R, De Ponti FF, Vanneste B, Zwicker C, Svedberg FR, Vanhalewyn T, Gonçalves A, Lippens S, Devriendt B, Cox E, Ferrero G, Wittamer V, Willaert A, Kaptein SJF, Neyts J, Dallmeier K, Geldhof P, Casaert S, Deplancke B, Ten Dijke P, Hoorens A, Vanlander A, Berrevoet F, Van Nieuwenhove Y, Saeys Y, Saelens W⁺, Van Vlierberghe H⁺, Devisscher L⁺, Scott CL⁺.
Cell, 2022. Pubmed

Expanding dendritic cell nomenclature in the single-cell era.
Ginhoux F, Guilliams M, Merad M.
Nature Reviews Immunol, 2022. Pubmed

Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues.
Scheyltjens I^*, Van Hove H^*, De Vlaminck K, Kancheva D, Bastos J, Vara-Pérez M, Pombo Antunes AR, Martens L, Scott CL, Van Ginderachter JA, Saeys Y, Guilliams M, Vandamme N, Movahedi K.
Nature Protoc, 2022. Pubmed

Liver macrophages in health and disease.
Guilliams M, Scott CL.
Immunity, 2022. Pubmed

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment. Bosteels C^*, Van Damme KFA^*, De Leeuw E, Declercq J, Maes B, Bosteels V, Hoste L, Naesens L, Debeuf N, Deckers J, Cole B, Pardons M, Weiskopf D, Sette A, Weygaerde YV, Malfait T, Vandecasteele SJ, Demedts IK, Slabbynck H, Allard S, Depuydt P, Van Braeckel E, De Clercq J, Martens L, Dupont S, Seurinck R, Vandamme N, Haerynck F, Roychowdhury DF, Vandekerckhove L, Guilliams M⁺, Tavernier SJ⁺, Lambrecht BN⁺.
Cell Rep Med, 2022. Pubmed

Does tissue imprinting restrict macrophage plasticity?
Guilliams M, Svedberg FR.
Nature Immunol, 2021. Pubmed

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Pombo Antunes AR^*, Scheyltjens I^*, Lodi F, Messiaen J, Antoranz A, Duerinck J, Kancheva D, Martens L, De Vlaminck K, Van Hove H, Kjølner Hansen SS, Bosisio FM, Van der Borght K, De Vleeschouwer S, Sciot R, Bouwens L, Verfaillie M, Vandamme N, Vandenbroucke RE, De Wever O, Saeys Y, Guilliams M, Gysemans C, Neyns B, De Smet F, Lambrechts D, Van Ginderachter JA⁺, Movahedi K⁺.
Nature Neurosci, 2021. Pubmed

Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis. Huang X, Ferris ST, Kim S, Choudhary MNK, Belk JA, Fan C, Qi Y, Sudan R, Xia Y, Desai P, Chen J, Ly N, Shi Q, Bagadia P, Liu T, Guilliams M, Egawa T, Colonna M, Diamond MS, Murphy TL, Satpathy AT, Wang T, Murphy KM. Immunity, 2021. Pubmed

The conventional dendritic cell lineage is born.
Guilliams M, Scott CL.
Nature Reviews Immunol, 2021. Pubmed

Establishment and Maintenance of the Macrophage Niche.
Guilliams M^*, Thierry GR^*, Bonnardel J^*, Bajenoff M^*.
Immunity, 2020. Pubmed

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury. Ydens E^*, Amann L^*, Asselbergh B, Scott CL, Martens L, Sichien D, Mossad O, Blank T, De Prijck S, Low D, Masuda T, Saeys Y, Timmerman V, Stumm R, Ginhoux F, Prinz M⁺, Janssens S⁺, Guilliams M⁺. Nature Neurosci, 2020. Pubmed

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes. Lavaert M, Liang KL, Vandamme N, Park JE, Roels J, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Vandekerckhove B, Leclercq G, Regev A, Van Vlierberghe P, Guilliams M, Teichmann SA, Saeys Y, Taghon T.
Immunity, 2020. Pubmed

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection. Bosteels C^*, Neyt K^*, Vanheerswynghels M, van Helden MJ, Sichien D, Debeuf N, De Prijck S, Bosteels V, Vandamme N, Martens L, Saeys Y, Louagie E, Lesage M, Williams DL, Tang SC, Mayer JU, Ronchese F, Scott CL, Hammad H, Guilliams M⁺, Lambrecht BN⁺.
Immunity, 2020. Pubmed

ImmGen at 15.
Immunological Genome Project.
Nature Immunol, 2020. Pubmed

Myeloid Cells TREM Down Anti-tumor Responses.
Bugler-Lamb A, Guilliams M.
Cell, 2020. Pubmed

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. Van Hove H, Martens L, Scheyltjens I, De Vlaminck K, Pombo Antunes AR, De Prijck S, Vandamme N, De Schepper S, Van Isterdael G, Scott CL, Aerts J, Berx G, Boeckxstaens GE, Vandenbroucke RE, Vereecke L, Moechars D, Guilliams M, Van Ginderachter JA^*, Saeys Y^*, Movahedi K.
Nature Neurosci, 2019. Pubmed

Decrypting DC development.
Guilliams M, Tamura T.
Nature Immunol, 2019. Pubmed

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche. Bonnardel J^*, TJonck W^*, Gaublomme D, Browaeys R, Scott CL, Martens L, Vanneste B, De Prijck S, Nedospasov SA, Kremer A, Van Hamme E, Borghgraef P, Toussaint W, De Bleser P, Mannaerts I, Beschin A, van Grunsven LA, Lambrecht BN, Taghon T, Lippens S, Elewaut D, Saeys Y⁺, Guilliams M⁺.
Immunity, 2019 Pubmed

Quorum sensing in the immune system.
Antonioli L, Blandizzi C, Pacher P, Guilliams M, Haskó G.
Nature Reviews Immunol, 2018. Pubmed

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.
Scott CL^*, TJonck W^*, Martens L, Todorov H, Sichien D, Soen B, Bonnardel J, De Prijck S, Vandamme N, Cannoodt R, Saelens W, Vanneste B, Toussaint W, De Bleser P, Takahashi N, Vandenabeele P, Henri S, Pridans C, Hume DA, Lambrecht BN, De Baetselier P, Milling SWF, Van Ginderachter JA, Malissen B, Berx G, Beschin A⁺, Saeys Y⁺, Guilliams M⁺.
Immunity, 2018. Pubmed

Cellular origin of human cardiac macrophage populations.
Svedberg FR, Guilliams M.
Nature Med, 2018. Pubmed

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.
De Schepper S^*, Verheijden S^*, Aguilera-Lizarraga J, Viola MF, Boesmans W, Stakenborg N, Voytyuk I, Schmidt I, Boeckx B, Dierckx de Casterlé I, Baekelandt V, Gonzalez Dominguez E, Mack M, Depoortere I, De Strooper B, Sprangers B, Himmelreich U, Soenen S, Guilliams M, Vanden Berghe P, Jones E, Lambrechts D, Boeckxstaens G.
Cell. 2018. Pubmed

Developmental and Functional Heterogeneity of Monocytes.
Guilliams M^*, Mildner A^*, Yona S^*.
Immunity, 2018. Pubmed

Tissue Unit-ed: Lung Cells Team up to Drive Alveolar Macrophage Development.
Scott CL, Guilliams M.
Cell, 2018. Pubmed

Macrophage, a long-distance middleman.
Guilliams M.
Science, 2017. Pubmed

Does niche competition determine the origin of tissue-resident macrophages?
Guilliams M, Scott CL.
Nature Reviews Immunol, 2017. Pubmed

A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes. Machiels B^*, Dourcy M^*, Xiao X, Javaux J, Mesnil C, Sabatel C, Desmecht D, Lallemand F, Martinive P, Hammad H, Guilliams M, Dewals B, Vanderplasschen A, Lambrecht BN, Bureau F, Gillet L.
Nature Immunol, 2017. Pubmed

A Matter of Perspective: Moving from a Pre-omic to a Systems-Biology Vantage of Monocyte-Derived Cell Function and Nomenclature.
Guilliams M, Malissen B.
Immunity, 2016. Pubmed

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells.
Scott CL, Zheng F, De Baetselier P, Martens L, Saeys Y, De Prijck S, Lippens S, Abels C, Schoonooghe S, Raes G, Devoogdt N, Lambrecht BN, Beschin A⁺, Guilliams M⁺.
Nature Commun, 2016. Pubmed

Tissue-Resident Macrophage Ontogeny and Homeostasis.
Ginhoux F, Guilliams M.
Immunity, 2016. Pubmed

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages. van de Laar L, Saelens W, De Prijck S, Martens L, Scott CL, Van Isterdael G, Hoffmann E, Beyaert R, Saeys Y, Lambrecht BN, Guilliams M.
Immunity, 2016. Pubmed

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2. Scott CL^*, Soen B^*, Martens L, Skrypek N, Saelens W, Taminau J, Blancke G, Van Isterdael G, Huylebroeck D, Haigh J, Saeys Y, Guilliams M, Lambrecht BN⁺, Berx G⁺.
Journal of Experimental Med, 2016. Pubmed

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Guilliams M^*, Dutertre CA^*, Scott CL^*, McGovern N^*, Sichien D^*, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GHL, Chung TJK, Chan DKH, Tan KK, Hon TLK, Fossum E, Bogen B, Choolani M, Chan JKY, Larbi A, Luche H, Henri S, Saeys Y, Newell EW, Lambrecht BN, Malissen B, Ginhoux F.
Immunity, 2016. Pubmed

IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively. Sichien D, Scott CL, Martens L, Vanderkerken M, Van Gassen S, Plantinga M, Joeris T, De Prijck S, Vanhoutte L, Vanheerswynghels M, Van Isterdael G, Toussaint W, Madeira FB, Vergote K, Agace WW, Clausen BE, Hammad H, Dalod M, Saeys Y, Lambrecht BN, Guilliams M.
Immunity, 2016. Pubmed

Macrophage precursors PLASTed INto alveolar space.
Guilliams M, Lambrecht BN.
Blood, 2016. Pubmed

A Death Notice for In-Vitro-Generated GM-CSF Dendritic Cells?
Guilliams M, Malissen B.
Immunity, 2015. Pubmed

The function of Fcγ receptors in dendritic cells and macrophages.
Guilliams M, Bruhns P, Saeys Y, Hammad H, Lambrecht BN.
Nature Reviews Immunol, 2014. Pubmed

Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny.
Guilliams M, Ginhoux F, Jakubzick C, Naik SH, Onai N, Schraml BU, Segura E, Tussiwand R, Yona S.
Nature Reviews Immunol, 2014. Pubmed

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.
Yona S^*, Kim KW^*, Wolf Y^*, Mildner A, Varol D, Breker M, Strauss-Ayali D, Viukov S, Guilliams M, Misharin A, Hume DA, Perlman H, Malissen B, Zelzer E, Jung S.
Immunity, 2013. Pubmed

Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen. Plantinga M^*, Guilliams M^*, Vanheerswynghels M, Deswarte K, Branco-Madeira F, Toussaint W, Vanhoutte L, Neyt K, Killeen N, Malissen B, Hammad H⁺, Lambrecht BN⁺.
Immunity, 2013. Pubmed

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. Guilliams M, De Kleer I, Henri S, Post S, Vanhoutte L, De Prijck S, Deswarte K, Malissen B, Hammad H, Lambrecht BN.
Journal of Experimental Med, 2013. Pubmed

Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Tamoutounour S^*, Guilliams M^*, Montanana Sanchis F, Liu H, Terhorst D, Malosse C, Pollet E, Ardouin L, Luche H, Sanchez C, Dalod M, Malissen B⁺, Henri S⁺.
Immunity, 2013. Pubmed